Article Details


B Imhof, P Xiao & I Angelova-Fischer.
Non Invasive Diagnostic Techniques in Clinical Dermatology (Editors: E Berardesca, HI. Maibach & K-P Wilhelm), 345-352, Springer Verlag 2014.
Print ISBN: 978-3-642-32108-5, Online ISBN 978-3-642-32109-2.



Closed-chamber instruments bring a new dimension to skin barrier measurement because they overcome the main limitation of open-chamber instruments, namely their vulnerability to disturbance from external air movements. This makes it possible for TEWL measurements to migrate away from the well-controlled laboratory environment, into the workplace or clinic. This and other aspects of their design liberate them from many of the restrictions and precautions recommended in the now outdated TEWL guidelines.
The two closed-chamber instruments described in this chapter differ in measurement principle, concept and design. The AquaFlux™, which uses the condenser-chamber method of measurement, is a bench-top, mains-powered instrument. The VapoMeter, which uses the unventilated-chamber method of measurement, is a self-contained, battery-powered instrument. Their performance characteristics are also quite different, with accuracy, sensitivity and repeatability the main features of the AquaFlux™; speed and mobility the main features of the VapoMeter.


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