TOWLAtopic Eczema/Dermatitis and AllergyMiceIn vitro – Franz cellIn vitro – Skin IntegrityCultured cellsSkin StrippingSkin penetration – in vivo measurementsTEWL on FaceSnakesNew born babiesIn vitro experimentation on porcine skinScalp, nasolabial, lipCanineSkin ExplantsVarious

TOWL

An investigation of how fungal infection influences drug penetration through onychomycosis patient’s nail plates
W.J. McAuley, S.A. Jonesb, M.J. Traynora, S. Guesnéa, S. Murdanc, M.B. Brown
European Journal of Pharmaceutics and Biopharmaceutics, 102, 178-184, May 2016
UV-curable gels as topical nail medicines: In vivo residence, anti-fungal efficacy and influence of gel components on their properties
L.V. Kerai, S. Hilton, M. Maugueret, B.B. Kazi, J. Faull, S. Bhakta, S. Murdan
International Journal of Pharmaceutics, 514(1):244-254, 2016
Hair and Nail Water-holding Capability Measurements by using Condenser-TEWL Method
P. Xiao, Y. Cui, L.I. Ciortea, E.P. Berg & R.E. Imhof
IJCS, 34(1), 12–16, 2012
Opto-thermal Radiometry for In-vivo Nail Measurements
P. Xiao, L.I. Ciortea, H. Singh, E.P. Berg & R.E. Imhof
Journal of Physics: Conference Series, 214(1), 012008, 2010
In-vivo Transungual Iontophoresis: Effect of DC Current Application on Ionic Transport and on Transonychial Water Loss
J. Dutet, & M.B. Delgado-Charro
Journal of Controlled Release, 140(2), 117-25, 2009
A few Aspects of Transonychial Water Loss (TOWL): Inter-individual, and Intra-individual Inter-finger, Inter-hand and Inter-day Variabilities, and the Influence of Nail Plate Hydration, Filing and Varnish
S. Murdan, D. Hinsu & M. Guimier
Eur J Pharm Biopharm, 2008, 70, 684-689, 2008

Mice

Deep phenotyping and lifetime trajectories reveal limited effects of longevity regulators on the aging process in C57BL/6J mice
K. Xie, H. Fuchs, et al, Nat Commun 13, 6830, 2022
Advanced Characterization of Imiquimod-Induced Psoriasis-Like Mouse Model
M. Jabeen, Anne-Sophie Boisgard, A. Danoy, N. El Kholti, Jean-Paul Salvi, R. Boulieu, B. Fromy, B. Verrier and M. Lamrayah, Pharmaceutics. 2020; 12(9):789
Lobelia chinensis Extract and Its Active Compound, Diosmetin, Improve Atopic Dermatitis by Reinforcing Skin Barrier Function through SPINK5/LEKTI Regulation
No-June Park, Beom-Geun Jo, Sim-Kyu Bong, Sang-a Park, S. Lee, Y. K. Kim,
M. H. Yang, Su-Nam Kim, Int. J. Mol. Sci., 2022, 23, 8687
Deep Phenotyping and Lifetime Trajectories Reveal Limited Effects of Longevity Regulators on the Aging Process in C57BL/6J
K. Xie et al, bioRxiv, 2022, 03.25.485824
Nymphoides peltata Root Extracts Improve Atopic Dermatitis by Regulating Skin Inflammatory and Anti-Oxidative Enzymes in 2,4-Dinitrochlorobenzene (DNCB)-Induced SKH-1 Hairless Mice
Tae-Young Kim, No-June Park, H. Jegal, Jin-Hyub Paik, S. Choi, Su-Nam Kim, and M. H. Yang, Antioxidants 2023, 12, 873
Deep Phenotyping and Lifetime Trajectories Reveal Limited Effects of Longevity Regulators on the Aging Process in C57BL/6J
K. Xie et al, bioRxiv, 2022, 03.25.485824
Compound K improves skin barrier function by increasing SPINK5 expression
N.-J. Park, S.-K. Bong, S. Lee, Y. Jung, H. Jegal, J. Kim, S.-K. Kim, Y. K. Kim, S.-N. Kim
Journal of Ginseng Research, published November 2019
Topical Application of Neem Leaves Prevents Wrinkles Formation in UVB-exposed Hairless Mice
H.T.T. Ngo, E. Hwang, S-A. Seo, B. Park, Z-w. Sun, M. Zhang, Y-K. Shin & T-H. Yi
Journal of Photochemistry and Photobiology B: Biology, 169, 161-170, 2017
Drug Permeation and Barrier Damage in Leishmania-infected Mouse Skin
K. Van Bocxlaer, V. Yardley, S. Murdan & S.L. Croft
J Antimicrob Chemother, 71(6), 1578-85, 2016
Temporal and spatial features of the formation of DNA adducts in sulphur mustard-exposed skin
M. Batal, I. Boudry, S. Mouret , J. Wartelle , S. Emorine, M. Bertoni , I. Bérard, C. Cléry-Barraud,
T. Douki
Toxicology and Applied Pharmacology, 273(3), 644-650, 15 December 2013
Time Course of Skin Features and Inflammatory Biomarkers after Liquid Sulfur Mustard Exposure in SKH-1 Hairless Mice
S. Mouret, J. Wartelle, M. Batal, S. Emorine, M. Bertoni, T. Poyot, C. Cléry-Barrauda, N. E. Bakdouri, A. Peinnequin, T. Douki & I. Boudry. Toxicol Lett, 232(1), 68-78, 2014
Topical Efficacy of Dimercapto-chelating Agents against Lewisite-induced Skin Lesions in SKH-1 Hairless Mice
S. Mouret, J. Wartelle, S. Emorine, M. Bertoni, N. Nguon, C. Cléry-Barraud, F. Dorandeu & I. Boudry
Toxicology and Applied Pharmacology, 272(2), 291–298, 2013
Sulfur Mustard Cutaneous Injury Characterization based on SKH-1 Mouse Model: Relevance of Non-invasive Methods in terms of Wound Healing Process Analyses
C. Cléry-Barraud, N. Nguon, V. Vallet, C. Sentenac, E. Four, C. Arlaud, D. Coulon & I. Boudry
Skin Res Tech, 19(1), e146–e156, 2013

In vitro – Franz cell

Polymorphism, Nanostructures, and Barrier Properties of Ceramide-Based Lipid Films
P. Pullmannová, B. A. Čuříková-Kindlová, V. Ondrejčeková, A. Kováčik, K. Dvořáková, L. Dulanská, R. Georgii, A. Majcher, J. Maixner, N. Kučerka, J. Zbytovská, and K. Vávrová, ACS Omega 2023, 8, 422−435
The Importance of Free Fatty Chain Length on the Lipid Organization in the Long Periodicity Phase
C. M. Beddoes, D. E. Rensen, G. S. Gooris, M. Malfois and J. A. Bouwstra, Int. J. Mol. Sci. 2021, 22(7), 3679
Human Epidermal Zinc Concentrations after Topical Application of ZnO Nanoparticles in Sunscreens
Z. Khabir, A. M. Holmes, Yi-Jen Lai, L. Liang, A. Deva, M. A. Polikarpov, M. S. Roberts and A. V. Zvyagin
Int. J. Mol. Sci. 2021, 22(22), 12372
Effect of Application Amounts on In Vitro Dermal Absorption Test Using Caffeine and Testosterone
Jueng-Eun Im, H. Y. Kim, J. D. Lee, Jin-Ju Park, Kyung-Soo Kang, Kyu-Bong Kim, Pharmaceutics. 2021; 13(5):641
Comparison of physical enhancement technologies in the skin permeation of methyl amino levulinic acid (mALA)
Y. Jhanker, M. N. Mbano, T. Ponto, L. J. L. Espartero, M. Yamada, T. Prow, H. A. E. Benson, International Journal of Pharmaceutics 610, 2021, 121258
ω-O-Acylceramides but not ω-hydroxy ceramides are required for healthy lamellar phase architecture of skin barrier lipids
L. Opalka, J. M. Meyer, V. Ondrejcekova, L. Svatosova, F. P. W. Radner, K. Vavrova, J. Lipid Res., 2022, 63(6) 100226
Cholesterol sulfate fluidizes the sterol fraction of the stratum corneum lipid phase and increases its permeability
F. Fandrei, O. Engberg , L. Opalka , P. Jancalkova, P. Pullmannova, M. Steinhart, A. Kovacik, K. Vavrova, D. Huster, J. Lipid Res., 2022, 63(3) 100177
Permeability and microstructure of cholesterol-depleted skin lipid membranes and human stratum corneum
M. Sochorová, P. Audrlická, M. Cervená, A. Kovácik, M. Kopecná, L. Opálka, P. Pullmannová, K. Vávrová.
Journal of Colloid and Interface Science, 535, 227-238, February 2019
Development of novel alternative hair dyes to hazardous para-phenylenediamine
G. Venkatesan , Y. Dancik, A. Sinha , H. M. Kyaw , R. Srinivas , T. L. Dawson , M. Bigliardi, P. Bigliardi, G. Pastorin
Journal of Hazardous Materials 402, 123712, 2021
High concentration of the ester-linked ω-hydroxy ceramide increases the permeability in skin lipid model membranes
L. E. Uche, G. S. Gooris, J. A. Bouwstra , C. M. Beddoes
Biochimica et Biophysica Acta (BBA) – Biomembranes, 1863(1), 183487, January 2021
Acidic pH Is Required for the Multilamellar Assembly of Skin Barrier Lipids In Vitro
A. Novackova, I. Sagrafena, P. Pullmannova, G. Paraskevopoulos, A. Dwivedi, A. Mazumder,
K. Ruzickova, P. Slepicka, J. Zbytovska and K. Vavrova
Journal of Investigative Dermatology, 141(8), 1915-1921.e4, August 2021
The effects of LXR agonist T0901317 and LXR antagonist GSK2033 on morphogenesis and lipid properties in full thickness skin models
W.J. Heldera , W. A. Boitena , R. van Dijka , G. S. Goorisa , A. El Ghalbzourib , J. A. Bouwstra Biochimica et Biophysica Acta (BBA) – Molecular and Cell Biology of Lipids, 1865(2), 158546, February 2020
The effects of LXR agonist T0901317 and LXR antagonist GSK2033 on morphogenesis and lipid properties in full thickness skin models
W.J. Heldera , W. A. Boitena , R. van Dijka , G. S. Goorisa , A. El Ghalbzourib , J. A. Bouwstra Biochimica et Biophysica Acta (BBA) – Molecular and Cell Biology of Lipids, 1865(2), 158546, February 2020
Permeability and microstructure of cholesterol-depleted skin lipid membranes and human stratum corneum
M. Sochorová, P. Audrlická, M. Cervená, A. Kovácik, M. Kopecná, L. Opálka, P. Pullmannová, K. Vávrová.
Journal of Colloid and Interface Science, 535, 227-238, February 2019
Improved epidermal barrier formation in human skin models by chitosan modulated
dermal matrices
A. Mieremet, M. Rietveld, S. Absalah, J. van Smeden, J. A. Bouwstra, A. El Ghalbzouri
PLoS ONE 12(3): 2017
Skin Permeability Enhancement by Bacillus Subtilis Alkaline Protease: Application to Transdermal Drug Delivery
M.I. Nounou, T.I. Zaghloul, N.A. Ahmed, A.A. Eid & L.K. El-Khordagui
Int J Pharmaceutics, 529(1–2), 423-432, 2017
Ex-vivo permeation of enrofloxacin through shed skin of Python molurus bivittatus, as evaluated with a Franz cell
A. Ducrotte-Tassel, P. Kirilov, J.-P. Salvi, V. H. Tran, V. Dore, G. Marignac, C.-P. Pignon, S. Perrot,
R. Boulieu
Journal of Drug Delivery Science and Technology 36, 2016

In vitro – Skin Integrity

Dendrimer-mediated permeation enhancement of chlorhexidine digluconate: Determination of in vitro skin permeability and visualisation of dermal distribution
M. Kirkby, A. B. Sabri , D. J. Scurr, G. P. Moss
European Journal of Pharmaceutics and Biopharmaceutics, Volume 159, , Pages 77-87, February 2021
Effects of Surfactants on Skin Integrity

Changes in Skin Barrier Function after Repeated Exposition to Phospholipid-Based Surfactants and Sodium Dodecyl Sulfate In Vivo and Corneocyte Surface Analysis by Atomic Force Microscopy
C. Vater, A. Apanovic, C. Riethmüller, B. Litschaue, M. Wolzt, C. Valenta and V. Klang
Pharmaceutics, 13, 436, 2021

Sweat Gland Activity

Influence of Various Environmental Parameters on Sweat Gland Activity
R.L. McMullen, T. Gillece, G. Lu, D. Laura & S. Chen
J Cosmet Sci, 64(4), 243-60, 2013

Sweat Gland Activity

Estimation of sweat rates during cycling exercise by means of the closed chamber condenser technology
P. Clarys, R. Clijsen, A. O. Barel, R. Schouteden, B. van Olst & D. Aerenhouts
Skin Res Technol; 23(1):30-35, 2017

Cultured cells

Functional and proteomic analysis of a full thickness filaggrin-deficient skin organoid model
M. S. Elias1, S. C. Wright1, W. V. Nicholson, K. D. Morrison, A. R. Prescott, S. T. Have, P. D. Whitfield, A. I. Lamond, S. J. Brown
Open Research 2019, 4:134 Last updated: 05 NOV 2021

Skin Stripping

Dermal Delivery of Diclofenac Sodium—In Vitro and In Vivo Studies
F. Iliopoulos, C. Fu Goh, T. Haque, A, Rahma, M. E. Lane, Pharmaceutics, 2022, 14(10), 2106
Skin pharmacokinetics of diclofenac and co-delivered functional excipients
M. A. M. Tabosa, S. F. Cordery, K. A. J. White, A. L. Bunge, R. H. Guy, M. B. Delgado-Charro, International Journal of Pharmaceutics 614, 2022, 121469
Exploratory in vivo biophysical studies of stratum corneum lipid organization in human face and arm skin
M. Gorcea, M. E. Lane, D. J. Moore, International Journal of Pharmaceutics 622, 2022, 121887
Assessment of Drug Delivery Kinetics to Epidermal Targets In Vivo
M. Hoppel, M. A. M. Tabosa, A. L. Bunge,M. B. Delgado-Charro, R. H. Guy,
The AAPS Journal, 2021, 23:49
Compromising human skin in vivo and ex vivo to study skin barrier repair
T. Berkers, W.A. Boiten, S. Absalah, J. van Smeden, A.P.M. Lavrijsen, J.A. Bouwstra
BBA – Molecular and Cell Biology of Lipids, 1864(8), 1103-1108, August 2019
Comprehensive, Multimodal Characterization of an Imiquimod-Induced Human Skin Inflammation
Model for Drug Development

T. van der Kolk, S. Assil, R. Rijneveld, E. S. Klaassen, G. Feiss, E. Florencia, E. P. Prens, J. Burggraaf, M. Moerland, R. Rissmann & M. B.A. van Doorn, Clin Transl Sci., 11(6):607-61, Nov 2018

Dissolving Polyvinylpyrrolidone-based Microneedle Systems for In-vitro Delivery of Sumatriptan Succinate
P. Ronnander, L. Simon, H. Spilgies, A. Koch & S. Scherr
Europ J Pharm Sci, 114, 84-92, 2018
Potential of short-wave infrared spectroscopy for quantitative depth profiling of stratum lipids and water in dermatology corneum

A. Ezerskaia , N. E. Uzinbajakava, G. J. Puppels, J. de Sterke, P. J. CASPERS, H. P. Urbach & B. Varghese, Biomedical Optic Express, 2438, 9(5), pp 2436-2450, 2018

An in vitro Skin Penetration Model for Compromised Skin: Estimating Penetration of Polyethylene Glycol [14C]-PEG-7 Phosphate
S. Deya, H. Rotheb, L. Pagec, R. O’Connora, S. Farahmanda, F. Tonerc, R. Marsha, K. Wehmeyera
S. Zhoua
Skin Pharmacol Physiol; 28, 12–21, 2015
Influence of Niacinamide Containing Formulations on the Molecular and Biophysical Properties of the Stratum Corneum
D. Mohammed, J.M. Crowther, P.J. Matts, J. Hadgraft & M.E. Lane
Int J Pharm, 441(1-2), 192-201, 2013

Skin Explants

Optimization of topical formulations using a combination of in vitro methods to quantify the transdermal passive diffusion of drugs
J. Hummer, T. Birngruber, Frank Sinner, Leanne Page, Frank Toner, C. S. Roper, D. J. Moore, M. B. Baker, M. B. Bettex, International Journal of Pharmaceutics 620, 2022, 121737

Snakes

Hydric “Costs” of Reproduction: Pregnancy Increases Evaporative Water Loss in the Snake Vipera aspis
O. Lourdais, A. Dupoué, M. Guillon, G. Guiller, B. Michaud and D. F. DeNardo
Physiol Biochem Zool, 90(6), 663-672, Nov/Dec 2017
Microclimate preferences correlate with contrasted evaporative water loss in parapatric vipers at their contact zone
M. Guillon, G. Guiller, D. F. DeNardo, & O. Lourdais
Canadian Journal of Zoology, 92(1), January 2014

Skin penetration – in vivo measurements

Superior even skin tone and anti-ageing benefit of a combination of 4-hexylresorcinol and niacinamide
R. Shariff, Y. Du, M. Dutta, S, Kumar V, S. Thimmaiah, C. Doraiswamy, A. Kumari, Vaidehi Kale, N. Nair, S. Zhang, M. Joshi, U. Santhanam, Q. Qiang, A. Damodaran, Int J Cosmet Sci. 2022;44:103– 117
The Effect of Sun Tan Lotion on Skin by Using Skin TEWL and Skin Water Content Measurements
P. Xiao and D. Chen, Sensors. 2022; 22(9):3595
A Humectant-Rich Moisturizer Reduces Xerosis in Diabetic Feet and Susceptibility to an Irritant in Healthy Skin
M. Lodén, G. Wahlund, S. Michelson, Clin Dermatol J, 2022, 7(1): 000260
Prevention and Treatment of Fungal Skin Infections Using Cationic Polymeric Films
F. Ka-Ho Ho, A. Bolhuis, M. B. Delgado-Charro, Pharmaceutics, 2021, 13, 1161
Effect of hydroxypropyl-β-cyclodextrin in fluid and semi-solid
submicron emulsions on physiological skin parameters during regular in vivo application
A. Pany, M. Wohlgenannt, S. Klopprogge, M. Wolzt, T. Heuser, H. Kotisch, C. Valenta, V. Klang, International Journal of Cosmetic Science, 2021, 43, 263–268
Topical application of highly concentrated water-in-oil emulsions: Physiological skin parameters and skin penetration in vivo – A pilot study
L. Bindera, V. Klang, S. S. Rezaei, O. Neuer, Z. Zhang, D. J. Lunter, M. Wolzt, C. Valenta
International Journal of Pharmaceutics, 571, 118694, 25 November 2019
Noninvasive Skin Barrier Assessment: Multiparametric Approach and Pilot Study
J. G. M. Logger, J. I. Olydam, W. Woliner-van der Weg, P. E. J. van Erp
Cosmetics, 6(1), 20, 2019

In vitro experimentation on porcine skin

Microneedle-Mediated Permeation Enhancement of Chlorhexidine Digluconate: Mechanistic Insights Through Imaging Mass Spectrometry.
M. Kirkby, A. B. Sabri, D. Scurr, G. Moss, Pharm Res 39, 1945–1958, 2022
Facilitating in vitro Tape Stripping: Application of Infrared Densitometry for Quantification of Porcine Stratum Corneum Proteins
V. Klang, J.C. Schwarz, A. Hartl & C. Valenta
Skin Pharmacol Physiol, 24(5), 256-268, 2011
Semi-solid Sucrose Stearate-Based Emulsions as Dermal Drug Delivery Systems
V. Klang, J.C. Schwarz, N. Matsko, E. Rezvani, N. El-Hagin, M. Wirth & C. Valenta
Pharmaceutics, 3(2), 275-306, 2011
Transepidermal Water Loss for Probing Full-thickness Skin Barrier Function: Correlation with Tritiated Water Flux, Sensitivity to Punctures and Diverse Surfactant Exposures
E. Elmahjoubi, Y. Frum, G.M. Eccleston, S.C. Wilkinson & V.M. Meidan. Toxicology in Vitro, 23(7), 1429-35, 2009

Atopic Eczema/Dermatitis and Allergy

Skin biomarkers predict development of atopic dermatitis in infancy
M. R. Rinnov, Anne-Sofie Halling, T. Gerner, N. H. Ravn, M. H. Knudgaard, S. Trautner, S. M. I. Goorden, K. J. M. Ghauharali-van der Vlugt, F. S. Stet, L. Skov, S. F. Thomsen, A. Egeberg, A. L. L. Rosted, T. Petersen, I, Jakasa, C. Riethmüller, S. Kezic, J. P. Thyssen, Allergy. 2023;78:791–802
Rosa gallica and its active compound, cyanidin-3,5-O-diglucoside, improve skin hydration via the GLK signaling pathway
Ji-Won Seo, S. Jo, Y. S. Jung, Mohammad-Al Mijan, J. Cha, S. Hong, S. Byun, Tae-Gyu Lim, BioFactors. 2023;49(2):415–27
Dupilumab significantly improves skin barrier function in patients with moderate-to-severe atopic dermatitis
E. Berdyshev, E. Goleva, R. Bissonnette. I. Bronova, A. S. Bronoff. B. N. Richers, S. Garcia.
M. Ramirez-Gama, P. Taylor, A. Praestgaard, I. Agueusop, P. Jurvilliers, M. Boguniewicz, N. A. Levit, A. B. Rossi, A. Zhang, D.Y. M. Leung, Allergy. 2022;77:3388–3397
Study Protocol for a Randomised Controlled Trial Investigating the Effects of Maternal Prebiotic Fibre Dietary Supplementation from Mid-Pregnancy to Six Months Post-Partum on Child Allergic Disease Outcomes
D. J. Palmer, J. Keelan, J, Garssen, K. Simmer, M. C. Jenmalm, R. Srinivasjois, D. Silva and Susan L. Prescott, Nutrients 2022, 14, 2753
Munich atopy prediction study (MAPS): protocol for a prospective birth cohort addressing clinical and molecular risk factors for atopic dermatitis in early childhood
S. Preis, L. Schmidt, L. Tizek, M. Schielein; V. Lang, R. Bleuel, A. Duswald; S. Sitaru; A. Blasini, C. Gasteiger et al, BMJ Open 2022;12:e059256
Characterization and ex vivo evaluation of excised skin samples as substitutes for human dermal barrier in pharmaceutical and dermatological studies
D. Kocsis, V. Klang, Eva-Maria Schweiger, Z. Varga-Medveczky, A. Mihály, C. Pongor, Z. Révész, Z. Somogyi, F. Erdő, SkinResTechnol.2022;28:664–676
Randomized controlled pilot trial with ion-exchange water softeners to prevent eczema (SOFTER trial)
Z. K. Jabbar-Lopez, B. Ezzamouri. A. Briley, D. Greenblatt, N. Gurung, J. R. Chalmers, K. S. Thomas, T. Frost, S. Kezic, J. E. A. Common, S. Danby 8 | M. J. Cork 8 | J. L. Peacock 9,10 | C. Flohr. Clin Exp Allergy. 2022;52:405–415. doi:10.1111/cea.14071
Effects of ultra-pure soft water on the hands of nurses in a neonatal intensive care unit: A randomized crossover study
K. Okazaki, Y. Fujino, Y. Morikawa, Contact Dermatitis. 2022;87:521–527
Evaluation of In Vitro Skin Permeation of Enzymatically Synthesized Phloridzin Acetates from Emulsions and Liposomes Dispersed in Gel
A. Milivojevi, M. ́Corovi, M. Simovi, K. Banjanac, R. Pjanovi, and D. Bezbradica, Eur. J. Lipid Sci. Technol. 2022, 124, 2200073
Longitudinal analysis of the effect of water hardness on atopic eczema: evidence for gene–environment interaction
Z.K. Jabbar‐Lopez, J. Craven, K. Logan, D. Greenblatt, T. Marrs, S. Radulovic, W.H.I. McLean, G. Lack, D.P. Strachan, M.R. Perkin, J.L. Peacock, C. Floh, British Journal of Dermatology, Volume 183, Issue 2, 1 August 2020, Pages 285–293
Gut microbiota development during infancy: Impact of introducing allergenic foods
T. Marrs, Jay-Hyun Jo, M. R. Perkin, D. W. Rivett, A. A. Witney, K. D. Bruce, K. Logan, J. Craven, S. Radulovic, S. A. Versteeg, R. van Ree, W. H. I. McLean, D. P. Strachan, G. Lack, H. H. Kong, and C. Flohr
Journal of Allergy and Clinical Immunology, 147(2), 613-621.e9, February 2021
The molecular features of normal and atopic dermatitis skin in infants, children, adolescents, and adults
Y. Renert-Yuval, E. Del Duca, A. B. Pavel, M. Fang, R. Lefferdink, J. Wu, A. Diaz, Y. D. Estrada, T. Canter, N. Zhang, A. Wagner, S. Chamlin, J. G. Krueger, E. Guttman-Yassky and A. S. Paller
Journal of Allergy and Clinical Immunology, 148(1), 148-163, July 2021
Association on of frequent moisturizer use in early infancy with the development of food allergy
M. R. Perkin, K. Logan, T. Marrs, S. Radulovic, J. Craven, R. J. Boyle, J. R. Chalmers, H. C. Williams, S. A. Versteeg, R. van Ree, G. Lack and C. Flohr
Journal of Allergy and Clinical Immunology, 147(3), 967-976.e1, March 2021
Multi parametric biophysical assessment of treatment effects on xerotic skin
H. Stettler, J. M. Crowther, M. Brand, B. Lu, A. Boxshall, R. de Salvo, S. Laing, N. Hennighausen, S. Bielfeldt, P. Blenkiron
Skin Health and Disease, 1:e21, 2021
Topical anti-microbial peptide omiganan recovers cutaneous dysbiosis but does not improve clinical symptoms in patients with mild-to-moderate atopic dermatitis in a phase 2 randomized controlled trial
N. der Kolk, T. P.Buters, L. Krouwels, J. Boltjes, M. L.de Kam, H. der Wall, D. C.J.G.van Alewijk, Ellen H.A.van den Munckhof, M. J.Becker, G. Feiss ,E.F. Florencia, P. Prens, M. Moerland. J. Burggraaf, R. Rissmann, M. B.A. van Doorn
Journal of the American Academy of Dermatology, Available online 1 October 2020, In Press
Multi parametric biophysical assessment of treatment effects on xerotic skin
H. Stettler, J. M. Crowther, M. Brand, B. Lu, A. Boxshall, R. de Salvo, S. Laing, N. Hennighausen,
S. Bielfeldt, P. Blenkiron
Skin Health and Disease, 2021;1:e21
https://doi.org/10.1002/ski2.21
Skin tape proteomics identifies pathways associated with transepidermal water loss and allergen polysensitization in atopic dermatitis
E. Goleva, A. Calatroni, P. LeBeau, E. Berdyshev, P. Taylor, S. Kreimer, R. N. Cole, D. Y. M. Leung
Journal of Allergy and Clinical Immunology, 146(6), 1367-1378, 2020
Evolution of pathologic T-cell subsets in patients with atopic dermatitis from infancy to adulthood
T. Czarnowicki, H. He, T. Canter, J. Han, R. Lefferdink, T. Erickson, S. Rangel, N. Kameyama, H. Je Kim, A.B. Pavel, Y. Estrada, J.G. Krueger, A.S. Paller, E. Guttman-Yassky
The Journal of Allergy and Clinical Immunology, Atopic dermatitis and inflammatory skin disease, 145(1)215-228, January 2020
EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis
M.S. Elias, S.C. Wright, J. Remenyi, J.C. Abbott, S. E. Bray, C. Cole, S. Edwards, M. Gierlinski, M. Glok, J.A. McGrath. W. V. Nicholson, L. Paternoster, A. R. Prescott, S. T. Have, P. D. Whitfield, A. I. Lamond and S. J. Brown
Journal of Allergy and Clinical Immunology, 144(2), 470-481, August 2019
The Effect of Water Hardness on Surfactant Deposition after Washing and Subsequent Skin Irritation in Atopic Dermatitis Patients and Healthy Control Subjects
S.G. Danby, K. Brown, A.M. Wigley, J. Chittock, P.K. Pyae, C. Flohr & M.J. Cork. J Invest Derm, 138(1), 68-77, 2018
Molecular Signatures Order the Potency of Topically Applied Anti-inflammatory Drugs in Patients with Atopic Dermatitis
E. Guttman-Yassky, B. Ungar, K. Malik, D. Dickstein, M. Suprun, Y.D. Estrada, H. Xu, X. Peng, M. Oliva, D. Todd, T. Labuda, M. Suarez-Farinas & R. Bissonnette
Journal of Allergy and Clinical Immunology, 140(4) February 2017
Staphylococcus Aureus Density on Lesional and Nonlesional Skin is strongly associated with Disease Severity in Atopic Dermatitis
M. Tauber, S. Balica, C-Y. Hsu, C. Jean-Decoster, C. Lauze, D. Redoules, C. Viod, A-M. Schmitt, G. Serre, M. Simon & C.F. Paul
Journal of Allergy and Clinical Immunology, 137(4), 1272-4, 2016
Effects of a New Emollient-Based Treatment on Skin Microflora Balance and Barrier Function in Children with Mild Atopic Dermatitis
P. Bianchi, J. Theunis, C. Casas, C. Villeneuve, A. Patrizi, C. Phulpin, A. Bacquey, D. Redoulès, V. Mengeaud & A.M. Schmitt
Pediatr Dermatol, 33(2), 165-71, 2016
Association between Domestic Water Hardness, Chlorine, and Atopic Dermatitis Risk in Early Life: A Population-based Cross-sectional Study
M.R. Perkin, J. Craven, K. Logan, D. Strachan, T. Marrs, S. Radulovic, L.E. Campbell, S.F. MacCallum, W.H. Irwin McLean, G. Lack, C. Flohr
Journal of Allergy and Clinical Immunology, 138(2), 509-16, 2016
Staphylococcus Aureus Density on Lesional and Nonlesional Skin is strongly associated with Disease Severity in Atopic Dermatitis
M. Tauber, S. Balica, C-Y. Hsu, C. Jean-Decoster, C. Lauze, D. Redoules, C. Viod, A-M. Schmitt, G. Serre, M. Simon & C.F. Paul
Journal of Allergy and Clinical Immunology, 137(4), 1272-4, 2016
Effects of a New Emollient-Based Treatment on Skin Microflora Balance and Barrier Function in Children with Mild Atopic Dermatitis
P. Bianchi, J. Theunis, C. Casas, C. Villeneuve, A. Patrizi, C. Phulpin, A. Bacquey, D. Redoulès,
V. Mengeaud & A.M. Schmitt
Pediatr Dermatol, 33(2), 165-71, 2016
Association between Domestic Water Hardness, Chlorine, and Atopic Dermatitis Risk in Early Life: A Population-based Cross-sectional Study
M.R. Perkin, J. Craven, K. Logan, D. Strachan, T. Marrs, S. Radulovic, L.E. Campbell, S.F. MacCallum, W.H. Irwin McLean, G. Lack, C. Flohr
Journal of Allergy and Clinical Immunology, 138(2), 509-16, 2016
Development of a Cumulative Irritation Model for Incontinence-associated Dermatitis
J. Larner, H. Matar, V.S. Goldman & R.P. Chilcott
Arch Dermatol Res, 307(1), 39-48, 2015
Ultra-pure Soft Water Improves Skin Barrier Function in Children with Atopic Dermatitis: A Randomized, Double-blind, Placebo-controlled, Crossover Pilot Study
Y. Togawa, N. Kambe, N. Shimojo, T. Nakano, Y. Sato, H. Mochizuki, A. Tanaka, H. Matsuda & H. Matsue
J Dermatol Sci, 76(3), 269–271, 2014
Atopic Dermatitis and Disease Severity are the Main Risk Factors for Food Sensitization in Exclusively Breastfed Infants
C. Flohr, M. Perkin, K. Logan, T. Marrs, S. Radulovic, L.E. Campbell, S.F. MacCallum, W.H. Irwin McLean & G. Lack
J Invest Dermatol, 134(2), 345-50, 2014
Improvement of Skin Barrier Function in Atopic Dermatitis Patients with a new Moisturizer containing a Ceramide Precursor
E. Simpson, A. Böhling, S. Bielfeldt, C. Bosc & N. Kerrouche
J Dermatolog Treat, 24(2), 122-5, 2013
Formulation and Delivery of Topically Applied Drugs for the Treatment of Atopic Eczema and other Related Diseases
M. Tsang, PhD Thesis, University of Bath 2010
Filaggrin Loss-of-function Mutations are associated with Early-onset Eczema, Eczema Severity and Transepidermal Water Loss at 3 Months of Age
C. Flohr, K. England, S. Radulovic, W.H.I. McLean, L.E. Campbell, J. Barker, M. Perkin & G. Lack
Brit J Dermatol, 163(6), 1333–1336, 2010

TEWL on Face

In Vivo Assessment of Water Content, Trans-Epidermial Water Loss and Thickness in Human Facial Skin
E. Chirikhina, A. Chirikhin , P. Xiao, S. Dewsbury-Ennis 1 and F. Bianconi
Appl. Sci., 10(17), 6139, 2020
In vivo barrier challenge and long-term recovery in human facial skin
M. Gorcea, J. Hadgraft, M. E. Lane, D. J. Moore
International Journal of Cosmetic Science, 41, 250-256, 2012
Noninvasive Skin Barrier Assessment: Multiparametric Approach and Pilot Study
J. G. M. Logger, J. I. Olydam, W. Woliner-van der Weg, P. E. J. van Erp
Cosmetics, 6(1), 20, 2019
A proof-of-principle study comparing barrier function and cell morphology in face and body skin
M. Gorcea, M. E. Lane and D. J. Moore
International Journal of Cosmetic Science, 41, 613–616, 2019
Facial Skin Pigmentation is not related to Stratum Corneum Cohesion, Basal Transepidermal Water Loss, Barrier Integrity and Barrier Repair
R. Voegeli, A.V. Rawlings & B. Summers
IJCS, 37(2), 241-52, 2015
In-vivo Barrier Challenge and Initial Recovery in Human Facial Skin
M. Gorcea, J. Hadgraft, D.J. Moore & M.E. Lane
Skin Res Tech, 19(1), e375–e382, 2013
In vivo barrier challenge and long-term recovery in human facial skin
M. Gorcea, J. Hadgraft, M. E. Lane, D. J. Moore
International Journal of Cosmetic Science, 41, 250-256, 2012
Assessment of cumulative exposure to UVA through the study of asymmetrical facial skin aging
S. Mac-Mary, J.-M. Sainthillier, A. Jeudy, C. Sladen, C. Williams, M. Bell, P. Humbert
Clinical Interventions in Aging, 5, 277–284, 2010
Increased Basal Transepidermal Water Loss leads to Elevation of some but not all Stratum Corneum Serine Proteases
R. Vögeli, A.V. Rawlings, S. Doppler & T. Schreier
Int J Cosmet Sci, 30, 435-442, 2008
Profiling of Serine Protease Activities in Human Stratum Corneum and Detection of a Stratum Corneum Tryptase-like Enzyme
R. Vögeli, A.V. Rawlings, S. Doppler, J. Heiland & T. Schreier
Int J Cosmet Sci, 29(3), 191-200, 2007

New born babies

Association on of frequent moisturizer use in early infancy with the development of food allergy
M. R. Perkin, K. Logan, T. Marrs, S. Radulovic, J. Craven, R. J. Boyle, J. R. Chalmers, H. C. Williams, S. A. Versteeg, R. van Ree, G. Lack and C. Flohr
Journal of Allergy and Clinical Immunology, 147(3), 967-976.e1, March 2021
Barrier dysfunction in Atopic newBorns studY’ (BABY): protocol of a Danish prospective birth cohort study
T. Gerner, Anne-Sofie Halling, M. R. Rinnov, N. H. Ravn, M. H. Knudgaard, C. M. Bonefeld, C. Ewertsen, S. Trautner, I. Jakaša, S. Kezic, L. Skov, J. P. Thyssen
BMJ Open, Online issue publication July 12, 2020
Protocol for an outcome assessor- blinded pilot randomised controlled trial of an ion-exchange water softener for the prevention of atopic eczema in neonates, with an embedded mechanistic study: the Softened Water for Eczema Prevention (SOFTER) trial
Z. K Jabbar-Lopez, N. Gurung, D. Greenblatt, A. Briley, J. R Chalmers, K. S. Thomas, T. Frost, S, Kezic, J. E. A. Common, H. H. Kong, J. A. S, S. Danby, M. J. Cork, J. L Peacock, C. Flohr
BMJ Open, Online issue publication August 20, 2019
Olive Oil, Sunflower Oil or no Oil for Baby Dry Skin or Massage: A Pilot, Assessor-blinded, Randomized Controlled Trial (the Oil in Baby SkincaRE [OBSeRvE] Study)
A. Cooke, M.J. Cork, S. Victor, M. Campbell, S. Danby, J. Chittock & T Lavender
Acta Derm Venereol. 96(3), 323-30, 2016
Development of Stratum Corneum Chymotrypsin-like Protease Activity and Natural Moisturising Factors from Birth to 4 Weeks of Age compared to Adults
J. Chittock, A. Cooke, T. Lavender, K. Brown, A. Wigley, S. Victor, M.J. Cork & S.G. Danby
Br J Dermatol 175(4), 713-720, 2016
Randomized, Controlled Trial Evaluating a Baby Wash Product on Skin Barrier Function in Healthy,
Term Neonates
T. Lavender, C. Bedwell, S. A. Roberts, A. Hart, M. A. Turner, Lesley-Anne Carter, and
M. J. Cork
Journal of Obstetric, Gynecologic & Neonatal Nursing, 42(2), 203-214, March–April 2013
Effect on skin hydration of using baby wipes to clean the napkin area of newborn babies:
assessor-blinded randomised controlled equivalence trial
T. Lavender, C. Furber, M. Campbell, S. Victor, I. Roberts, C. Bedwell and M. J. Cork
BMC Pediatrics, 12:59, 2012
Infant Skin-cleansing Product versus Water: A Pilot Randomized, Assessor-blinded Controlled Trial
T. Lavender, C. Bedwell, E. O’Brien, M.J. Cork, M. Turner & A. Hart
BMC Pediatrics, 11:35, 2011

Scalp, nasolabial, lip

Effect of an oral probiotic formula on scalp and facial skin
condition, glucose, and lipid metabolism
P. Yu, X. Teng, T. Liu, Y. Li, J. Ni, S. Xue, J. Wang, Functional Foods in Health and Disease, 2022, 12(7): 394-409
Scalp application of the antioxidant piroctone olamine reduces hair shedding in an 8-week randomized, double-blind, placebo-controlled clinical study
M. G. Davis, M. P. Piliang, W. F. Bergfeld, T. L. Caterino, B. K. Fisher, J. P. Sacha, G J. Carr, LL T. Moulton, D. J. Whittenbarger, S. Punyani, J. R. Schwartz, 26|Int J Cosmet Sci., 2021;43(Suppl.1):26–33
Characterization and validation of an in vivo confocal Raman spectroscopy led tri-method approach in the evaluation of the lip barrier
S. Bielfeldt, S. Laing, T. Sadowski, H. Gunt, K.-P. Wilhelm
Skin Res Technol., 26:390–397, 2020
Deposition of plant lipids after single application of a lip care product determined by confocal raman spectroscopy, corneometry and transepidermal water-loss
S. Bielfeldt , J. Blaak, S. Laing , M. Schleißinger, C. Theiss, K-P Wilhelm & P. Staib
International Journal of Cosmetic Science, 41, 281–291, 2019
High Staphylococcus epidermidis Colonization and Impaired Permeability Barrier in Facial Seborrheic Dermatitis
Q. An, M. Sun, R.Q. Qi, L. Zhang, J.L. Zhai, Y.X. Hong, B. Song, H.D. Chen, X.H. Gao
Chinese Medical Journal, 130(14), July 20, 2017

Canine

Skin Barrier Reinforcement Effect Assessment of a Spot-on Based on Natural Ingredients in a Dog Model of Tape Stripping
A. Idée, M. Mosca and D. Pin, Vet. Sci., 2022, 9(8), 390