Article Details


B. Imhof & P. Xiao.
Computational Biophysics of the Skin (Editor: B. Querleux), 11, 333-352, Pan Stanford Publishing 2014. Print ISBN: 9789814463843 eBook ISBN: 9789814463850.



The aim of the model presented in this chapter is to provide a means to understand how skin interacts with the air in contact with it and how this interaction affects the steady-state SC properties of hydration and TEWL. The model represents in-vivo skin, but can also be adapted to represent ex-vivo or in-vitro constructs that mimic in-vivo skin, ie dry on top, wet underneath. The air-side uses a fluid dynamic representation of ambient air, but this can be adapted to represent the microclimate inside the measurement chambers of evaporimeters used for TEWL measurement, for example. The model can also be used to calculate changes following SC perturbations such as tape stripping. However, the model is restricted to steady-state properties – dynamic processes require a different approach. Also, this is a physics-based mathematical model, incapable of representing biological changes that undoubtedly accompany physical changes.


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