Conference Contribution Details
P Xiao, H Singh, X Ou, AR Caparnagiu, G Kramer and RE Imhof
Poster Presentation, SCC Annual Scientific Meeting & Technology Showcase, New York 2011.
Contacting solid-state image sensors can be used for a wide range of applications, well beyond their original purpose of fingerprint capture [1-3]. This research used a Fujitsu MBF200 sensor of 12.8 x 15mm active area and 50 x 50 µm spatial resolution. Each pixel is a fringing field capacitor whose capacitance value depends on the dielectric constant of the sample material in contact with it. Capacitance images of 8-bit greyscale resolution can be captured at rates up to 10 images per second using a USB connection to a PC.
The sensor was used to study solvent penetration into in-vivo skin. A small amount of solvent was applied to volar forearm skin for a predetermined time. After wiping dry, tape stripping was performed. Contact images were captured before and after solvent application, and after each strip. With DMSO and Glycerol, the images show clear contrast between the solvent and normal skin due to differences of dielectric constant. The results show that DMSO penetrated deeper than Glycerol, as traces of DMSO were found to be still visible after 10 strips, whereas Glycerol residues were found to have disappeared after only 5 strips. The strip sequence images can be analysed further to yield spatially resolved solvent concentration depth profiles that reveal skin heterogeneity effects.
|1.||Leveque, J.L. and Querleux, B. SkinChip, a new tool for investigating the skin surface in vivo. Skin Research and Technology 9: 343-347 (2003).|
|2.||Batisse, D., Giron F. and Leveque J.L. Capacitance imaging of the skin surface. Skin Research and Technology 12: 99-104 (2006).|
|3.||P Xiao, H Singh, X Zheng, E P Berg and R E Imhof, In-vivo Skin Imaging For Hydration and Micro Relief Measurements. Stratum Corneum V Conference, July 11-13, Cardiff, UK, 2007.|
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